Risk Stratification of Sudden Cardiac Death by Evaluating Myocardial Sympathetic Nerve Activity Using Iodine-123 Metaiodobenzylguanidine Scintigraphy in Patients with Chronic Heart Failure and Dilated Cardiomyopathy
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چکیده
A Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) has proven the efficacy of prophylactic implantable cardioverter defibrillator (ICD) use for chronic heart failure pa‐ tients without sustained ventricular tachycardia (SVT) and a history of ventricular fibril‐ lation, not restricted in those with myocardial infarction [1]. Since ICD is an expensive device, risk stratification is required to identify heart failure patients at high risk for sud‐ den death without SVT.
منابع مشابه
Metaiodobenzylguanidine scintigraphy of cardiac sympathetic innervation.
Metaiodobenzylguanidine (MIBG), a noradrenaline analogue,labelled with radioactive iodine I-123 is used for assessing pre-synaptic activity of the myocardial adrenergic system. The paper describes the mechanism of myocardial I-123-MIBG uptake and the relevant examination methods. It also refers to the necessity of standardising acquisition methods and assessment criteria in order to improve com...
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he sympathetic nervous system of the heart is critically involved in the maintenance of cardiovascular homoeostasis by regulating cardiac contractility, conduction, heart frequency and peripheral vasoconstriction.1 It has been shown that a dysfunctional cardiac sympathetic nervous system exerts detrimental effects on the structural and functional integrity of the myocardium, leading to a marked...
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متن کاملLong-term course and cardiac sympathetic nerve activity in patients with hypertrophic cardiomyopathy.
OBJECTIVE To investigate the relation between regional myocardial sympathetic nerve activity and the electrocardiographic and cardiac functional changes in hypertrophic cardiomyopathy. DESIGN A retrospective study to compare the findings of myocardial scintigraphy with iodine-123 metaiodobenzylguanidine (MIBG) and the serial electrocardiographic changes. SETTING Myocardial scintigraphy was ...
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تاریخ انتشار 2013